The Power of Smell

nosesmellWhat does the nose know?

A great deal.  The nose can identify more than 10,000 odor molecules.1

How does it do it?  The mechanism by which a person “reads” an odor molecule is a subject of controversy:   The long-time predominant view was that each olfactory receptor in the nose bonds with the odor molecules that are its match in terms of shape.2  A minority view has been that the key is not shape but vibration.  The idea is that the receptors can distinguish between two molecules that are identical in shape by passing current through them.3  The latter hypothesis has gained more traction through recent research, but there is no definitive answer4—and the correct answer may be “both”.

The nasal receptors transmit information about the odor molecule to the olfactory bulb5, which is sometimes (though not always)6 considered part of the brain’s limbic system.  In any event, the olfactory bulb operates in close conjuntion with the limbic system, which is known as the “emotional brain”.7   The olfactory bulb “communicates with your emotion processor, the amygdala, and your associative learning center, which is housed in the hippocampus.”  As a result, the things you smell are linked to the experience you’re having at the time you smell it8—and can subsequently elicit strong emotional responses.

Smell can be an early warning sign of danger, such as when you scent fire or rotting food or a gas leak.  The loss of the sense of smell, called asnomia, can be an early warning sign of maladies including Parkinson’s disease, Alzheimer’s, myasthenia gravis,9 multiple sclerosis, diabetes, and Huntington’s disease,  among others.10

The power of pleasant smells is being leveraged by the medical profession in the form of aromatherapy. At Memorial Sloan-Kettering Cancer Center in New York, doctors use scent to alleviate people’s anxiety during medical tests.  At Duke University Medical Center, menopausal women are being treated with fragrances to help reduce their depression and mood swings.11

Some researchers are decrying the way we obscure our native scents with perfume and recommending that we become more comfortable with our natural smell.12  If more broadly endorsed and taken to an extreme, this view could affect personal hygiene practices.  However, it seems unlikely that going “au natural” will take hold so long as people’s sense of smell—and their power to express displeasure at unpleasant odors—remains.

 

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  1. “How Does the Sense of Smell Work?”, HowStuffWorks, http://science.howstuffworks.com/life/human-biology/question139.htm
  2. Lisa Zyga,  “Quantum Explanation for How We Smell Gets New Support,” PhysOrg (Mar. 28, 2011),   http://phys.org/news/2011-03-quantum-explanation.html
  3. Clay Dillow, “Your Nose Could Use Quantum Tunneling to Distinguish Between Similar Molecules,” PopSci (Feb. 25, 2011), http://www.popsci.com/science/article/2011-02/your-nose-could-leverage-quantum-tools-distinguish-between-similar-molecules
  4. Bob Yirka,  “New Study Strengthens Olfactory-Vibration Theory,”  PhysOrg  (Jan. 29, 2013), http://phys.org/news/2013-01-olfactory-vibration-sensing-theory.html
  5. Eric H. Chudler, “The Nose Knows,” Neuroscience for Kids, http://faculty.washington.edu/chudler/nosek.htm
  6. Anthony Wright (University of Texas Health Science Center at Houston), “Chapter 4:  Limbic System:  Hippocampus,” http://neuroscience.uth.tmc.edu/s4/chapter05.html
  7. Sarah Dowdey, “How Smell Works,” How Stuff Works (n.d.) http://science.howstuffworks.com/life/human-biology/smell3.htm
  8. Science Channel, “How Do Certain Smells Bring Up Old Memories?” http://curiosity.discovery.com/question/how-certain-smells-bring-memories
  9. “Loss Of Smell Linked To Onset Of Parkinson’s Or Alzheimer’s,” Medical News Today (Oct. 22, 2012),  http://www.medicalnewstoday.com/articles/251756.php
  10. Mayo clinic staff, “Loss of Smell (Anosmia),” http://www.mayoclinic.com/health/loss-of-smell/MY00408/DSECTION=causes
  11. Prolitec Advanced Air Treatment Systems, “The Science of Smell,”    http://www.prolitec.com/science_of_smell.htm
  12. “Sissel Tolass:  The Science of Smell,” Nowness (Jan. 2, 2013),  http://www.nowness.com/day/2013/1/2/sissel-tolaas-the-science-of-smell

Time to Rethink the Traditional White Coat?

lab coat protectionIs the physician’s white hospital coat a protection for or a danger to patients?  Years ago, the United Kingdom, concerned that the fabric on the lower sleeve is rife with infectious matter, instituted a bare-below-the-elbows policy to reduce the risk of nosocomial infections (NI).  (Murphy 2007, Kerr 2008, Gray 2008) (To clarify, “bare below the elbows” only applies to the arms, not to a practitioner’s nether regions.)

The United States is taking longer to arrive at such a policy, despite the fact that in June 2009 the American Medical Association (AMA) House of Delegates passed a resolution to encourage the “adoption of hospital guidelines for dress codes that minimize transmission of nosocomial infections (NI).” (AMA 2009) One reason for hesitation:  The UK has not performed definitive studies to demonstrate that its “bare below the elbows” policy actually reduces nosocomial infections.

What is undeniable is that NI are a serious danger in the US.  In 2002 alone, there were 1.7 million nosocomial infections, which resulted in 99,000 deaths in the United States, at an estimated annual cost of $6.7 billion.  (Monina 2007, Graves 2004).  And studies have shown that physicians’ coat sleeves and pockets are often colonized with the types of bacteria that cause NI. (Varghese 1999, Loh 2000, Wong 1991, Amy 2008)

These facts make it imperative to resolve any danger associated with medical uniforms.  “Below the elbows” policies may be a starting point, but the AMA and hospitals should also be investigating other avenues of potential protection, such as novel fabrics that have antimicrobial properties “built into” them.

 

 

Endnotes

AMA, 2009.  “Resolution 720: Hospital Dress Codes for the Reduction of Nosocomial Transmission of Disease.

Amy, MT, AT Kerri et al.  2008.  “Bacterial Contamination of Health Care Workers’ White Coats.” Am J Infect Control 37(2) 101-105.

Graves, N. 2004. “Economics and Preventing Hospital-Acquired Infection.  Emerg. Infect. Dis.

Gray, S. 2007 Sep 17.  “Superbug Fears Kill Off Doctors’ White Coats.”  The Times. [Accessed 19 June 2008]. http://www.timesonline.co.uk/tol/news/uk/health/article2470379.ece

Kerr, C.  2008.  “Ditch that White Coat.” CMAJ 178(9):1127.

Loh, W, VV Ng, and J Holton. 2000. “Bacterial Flora on the White Coats of Medical Students.” J Hosp Infect 45(1):65-68.

Monina, R, and D Klevens, R Jonathan et al. 2007. “Estimates of Healthcare-Associated Infections.”  Public Health Reports 122:160-166.

Murphy, C. 2007 Sep 17.  “End for Traditional Doctor’s Coat.”  BBC News. [Accessed 19 June 2008].

Varghese, D and H Patel.  1999.  “Hand Washing. Stethoscopes and White Coats are Sources of Nosocomial Infection. BMJ 319(7208):519.

Wong, D, K Nye, and P. Hollis P. 1991. “Microbial Flora on Doctors’ White Coats. BMJ 303(6817):1602-1604.

CRE, Another Antibiotic-Resistant Germ

CRECRE, which stands for carbapenem-resistant Enterobacteriaceae, is a family of germs that, like MRSA, is resistant to antibiotics.  Escherichia coli (E. coli) is one example of Enterobacteriaceae, a normal part of the bacteria in the human gut, which can become carbapenem-resistant. Types of CRE are sometimes known as KPC (Klebsiella pneumoniae carbapenemase) and NDM (New Delhi Metallo-beta-lactamase).  KPC and NDM are enzymes that break down carbapenems and make them ineffective. (CDC n.d.)

Healthy people usually do not get CRE infections, which most often afflict people being treated for other conditions.  Patients whose care requires devices like ventilators, urinary catheters, or IV catheters, and patients who are taking long courses of certain antibiotics are most at risk for CRE infections. (CDC n.d.)

Between 2001 and 2011, the percentage of carbapenem-resistant Enterobacteriaceae infections reported by US hospitals rose nearly fourfold, from 1.2% to 4.2%.  Information from the first 6 months of 2102 suggests that the percentage of such infections has gotten slightly higher, at 4.6%.  CDC director Tom Frieden said that it was time to sound an alarm in order to address this threat. (Brunk 2013)  He characterized CRE as a “nightmare” for multiple reasons:  “First, they’re resistant to all or nearly all antibiotics….Second, they have high mortality rates. They kill up to half of people who get serious infections with them. And third, they can spread their resistance to other bacteria such as Escherichia coli and make E. coli resistant to those antibiotics also.” (Brunk 2013)

Endnotes

Brunk, Doug.  2013 Mar. 6.  “’Nightmare’ CRE Infections on the Rise.”  Family Practice News. Retrieved from http://www.familypracticenews.com/news/infectious-diseases/single-article/nightmare-cre-infections-on-the-rise-cdc-says/a0206becb5b1bb3c1e20b4b81a11f78e.html

Centers for Disease Control and Prevention.  (n.d.) Healthcare-Associated Infections.

Healthcare-Associated Infections

Healthcare-associated infections, or HAIs, are infections acquired while receiving treatment for another condition in a healthcare setting.  (HHS.gov [n.d.]).  They include almost every malady that is not part of the admitting diagnosis.  (Wilcox J. 2012)  Although they are sometimes referred to as hospital-acquired infections, they can be contracted anywhere healthcare is delivered, including inpatient settings, outpatient settings, and nursing homes or rehab centers.  HAIs may be caused by any infectious agent, including bacteria, fungi, and viruses.  (HHS.gov [n.d.]).

Risk factors for HAI include

  • Use of bloodstream, endotracheal, and urinary catheters
  • Surgical procedures
  • Injections
  • Contamination of the healthcare environment
  • Transmission of communicable diseases between patients and healthcare workers
  • Overuse or improper use of antibiotics  (HHS.gov [n.d.]).

HAIs are rife.  At any given time, about 1 in 20 inpatients has an infection related to hospital care.  These infections cost the US healthcare system billions of dollars each year. (HHS.gov [n.d.]).  According to one 2010 study, the average length of stay for someone with an HAI is more than 19 days longer than that of someone without an HAI.  On average, each HAI-afflicted patient in a hospital costs $43,000 more than a patient free of HAIs.  In 2007, HAI cost 99,000 lives, the majority of them from pneumonia and bloodstream infections. (–.  The Silver Book (n.d.))

The US Department of Health and Human Services (HHS) has identified the reduction of HAIs as an Agency Priority Goal.  In time, HHS believes that HAIs can be eliminated entirely. (HHS.gov [n.d.]).

 

Endnotes
HHS.gov (n.d.).  Health Care Associated Infections.  Retrieved from http://www.hhs.gov/ash/initiatives/hai/

(n.d.). The Silver Book:  Healthcare-Associated Infections.  Retrieved from http://www.silverbook.org/uploads/images/SilverBookHAI_FactSheet.pdf

Wilcox, J. (ed.), 2012. Hospital-Acquired Infections.

MRSA in the Locker Room

MRSAHe’s a superstar athlete and commonly considered virtually superhuman, but that didn’t prevent NFL quarterback Peyton Manning from contracting the antibiotic-resistant strain of staph known as MRSA (methicillin-resistant Staphylococcus aureus) a few years ago.  At the time, the NFL stressed that Manning in suffering from MRSA was far from alone:  “Staph infections are an issue across our country in all walks of life,” NFL spokesman Greg Aiello said.  (–Spotlight on Prevention Nov. 2008).  Among professional athletes, other victims of MRSA include baseball player Sammy Sosa, White Sox outfielder Álex Riós, Grizzlies forward Rudy Gay, Rockets forward Shane Battier, and Nuggets forward Kenyon Martin.  There’s an unconfirmed rumor that Patriots quarterback Tom Brady also suffered from MRSA in 2008. (Bucher 2010)  It’s estimated that 517 of 100,000 football players contracted MRSA between 2003 and 2005, compared to 32 of 100,000 people in the general population. (Stop MRSA NOW n.d.)

According to MedLine Plus Medical Encyclopedia, “Most staph germs are spread by skin-to-skin contact (touching).  A doctor, nurse, other health care provider, or visitors may have staph germs on their body that can spread to a patient.”  That makes it all the more important that caregivers not only have clean skin but clean uniforms and peripheral equipment such as curtains.  The online Physician Desk Reference advises, “The list of drugs that can kill MRSA keeps getting shorter.”  So prevention is the key, and ever more elusive, goal.

MRSA may be even more of a threat in the locker room than in healthcare facilities, since locker rooms are not subject to the same rigorous cleaning standards as hospitals.  (Bucher 2010)  Having skin abrasions and sharing training equipment or personal hygiene items are risk factors.  (Johnson DL 2009).   In its most lethal form, it can kill more people than HIV.  (Bucher 2010)

A 2010 study highlighting the danger of MRSA in the locker room provided detailed advice on prevention:  In addition to advocating frequent hand washing and showering, they advised against sharing towels, athletic gear, water bottles, disposable razors or hair clippers.  They also recommended that all clothing and equipment be laundered or disinfected every day. (Freeman 2007)

Endnotes Bucher, Ric. 2010. “This Is a Staph Infection.” ESPN 2010-2011 NBA Preview. Retrieved from http://sports.espn.go.com/nba/preview2010/news/story?id=5706491

Freeman, David. June 23, 2010. “MRSA Alert: Do Locker Rooms Breed Deadly Infections? Just Ask College Wrestler Kyle Frey.” CBS News. Retrieved from http://www.cbsnews.com/8301-504763_162-20008624-10391704.html

Johnson, DL. Mar. 2010. “Locker-Room-Acquired MRSA.” Orthopedics. Retrieved from http://www.healio.com/orthopedics/infection/journals/ortho/%7Bfcb4b558-a625-4529-8516-e0e37c410f78%7D/locker-roomacquired-mrsa

Stop MRSA NOW. (n.d.). “Your Locker Room or Gym.” –, Nov. 2008. “Peyton Manning’s Staph Infection.” Spotlight on Prevention.

Global Handwashing Day Tip: Fist Bump for Hand Hygiene

world-handwashing-day

Global Handwashing Day on October 15 celebrates public hand hygiene—the culture of washing one’s hands with soap. Simultaneously the day seeks to raise awareness of the benefits of handwashing and assess the state of handwashing in every country.

The habit of handwashing with soap is the most effective and inexpensive way to prevent diarrheal and acute respiratory infections, which are together responsible for the majority of all child deaths. Global Handwashing Day focuses on children because their habits are more malleable and because they are the most affected by the consequences of not washing with soap. More than 200 million people take part in Global Handwashing Day. Their website includes games, videos, posters and much more.

While we’re talking about celebrating: This past summer, the Association for Professionals in Infection Control and Epidemiology (APIC) awarded its first Distinguished Scientist Award to Elaine Larson for her contributions to handwashing and epidemiological research. She’s the Associate Dean for Research at the Columbia School of Nursing and professor of epidemiology at Mailman School of Public Health, and a co-author of the Centers for Disease Control and Prevention (CDC) guidelines on hand hygiene for healthcare workers.

Dr. Larson was one of the first advocates for alcohol-based hand sanitizers. She presented the results of her research on the effects of electronic monitoring on hand hygiene compliance at IDWeek 2012 in San Diego.

Notice we didn’t say “High Five” in the title of this post. And we definitely wouldn’t offer a hardy handshake. Recent research from West Virginia University published in the Journal of Hospital Infection explores the role of the handshake in bacterial transmission. Fist bumps in place of handshakes may reduce transmission due to the fist’s smaller contact surface area and the shorter duration of the bump. Maybe the kids on the street have a good thing going!

PurThreadTM Technologies Inc. is dedicated to developing proprietary antimicrobial textile technology. Our patent-pending, integration technology and fiber formulations incorporate an EPA-registered antimicrobial additive into every fiber and yarn to protect the fabric from degradation. Learn more about our antimicrobial textile technology.

PurThread also makes a range of freshness products for other markets such as the military, emergency first responders and performance athletic wear in which our next-generation technology and fiber formulations expand the high performance options available to protect fabrics from odor, mold and mildew causing bacteria.

MRSA Rates Decline in Hospitals; Rise in Children

MRSA AwarenessWorld MRSA Day (October 2) is focused on public education about prevention of methicillin-resistant Staphylococcus aureus (MRSA) infections in healthcare settings as well as in the community. It is well timed, as a study in the Journal of the American Medical Association (JAMA) called National Burden of Invasive Methicillin-Resistant Staphylococcus aureus Infections, United States, 2011 cites declines of 27-54 percent in healthcare-associated MRSA infections, but a relatively flat rate of change in the incidence of community-associated infections.

The authors report a 31 percent drop from 2005 estimates of overall incidents of MRSA infections to approximately 80,000 in 2011. Thanks most likely to infection control efforts and hand hygiene, healthcare-associated MRSA infections are responsible for the majority of the decline. That’s the good news. The decline during that same period in community-associated infections was only about 5 percent. That’s part of the bad news.

The worse news is that according to Trends in Invasive Methicillin-Resistant Staphylococcus aureus Infections a study published in Pediatrics, the incidence of community-associated MRSA is rising. Between 2005 and 2010 the incidence rose from 1.1 to 1.7 cases per 100,000 children, a modeled annual increase of around 10 percent. Infants aged 3 to 90 days are especially susceptible, with and incidence of 43.9 cases per 100,000 children. African-American children also had a higher incidence of MRSA at 6.7 per 100,000 than children of other races who averaged 1.6 per 100,000.

The decline in healthcare-associated MRSA is heartening and indicates the success of MRSA prevention efforts in hospitals. However, the problem seems to be moving to the community, and especially the most vulnerable among us, the children. While healthcare facilities can’t let up on their infection control efforts, community-based infection prevention methods beyond the CDC’s common sense recommendations have taken on even more urgency. The authors of the Pediatrics study call for a targeted program to help people in households reduce the spread of MRSA.

PurThreadTM Technologies Inc. is dedicated to developing proprietary antimicrobial textile technology. Our patent-pending, integration technology and fiber formulations incorporate an EPA-registered antimicrobial additive into every fiber and yarn to protect the fabric from degradation. Learn more about our antimicrobial textile technology.

PurThread also makes a range of freshness products for other markets such as the military, emergency first responders and performance athletic wear in which our next-generation technology and fiber formulations expand the high performance options available to protect fabrics from odor, mold and mildew causing bacteria.

Climate Change Spreading Disease Faster?

F164589256 frying panIs climate change affecting how diseases spread? The consensus of scientific opinion indicates that it probably is, and almost certainly will in the future. An increase in disease and parasitism is noticeable. While it’s sometimes hard to prove and isolate what causes more rapid infectious disease transmission, there’s little doubt that warmer temperatures have made some previously inhospitable geographies well-suited for the insects or bacteria that carry and spread the disease. Malaria spreading higher on mountains in East Africa, where carrier mosquitoes formerly couldn’t survive, is but one example.

A recent research study reported in Science magazine, Climate Change and Infectious Diseases: From Evidence to a Predictive Framework highlighted some of the issues involved, including more rapid development of some parasite organisms, added stresses on certain ecosystems, and threats to sustaining agricultural crops and game species.  The multidisciplinary research team reflects the complex and interrelated nature of the problem and thus, any proposed solution.

If we can truly understand the relationship between climate change and disease transmission, we can prepare for disasters and take some preventive actions.  The researchers held out the hope that predictions that tied infectious disease transmission effects to a specific amount of climate warming could also trigger specific preventive or mitigating actions. Monitoring and surveillance, vector control, or food security management were among the possible actions listed. The study  included a research agenda to determine and support those actions.

 

PurThreadTM Technologies Inc. is dedicated to developing proprietary antimicrobial textile technology. Our patent-pending, integration technology and fiber formulations incorporate an EPA-registered antimicrobial additive into every fiber and yarn to protect the fabric from degradation. Learn more about our antimicrobial textile technology.

PurThread also makes a range of freshness products for other markets such as the military, emergency first responders and performance athletic wear in which our next-generation technology and fiber formulations expand the high performance options available to protect fabrics from odor, mold and mildew causing bacteria.

Environmental Disservice?

iStock_000005585983Small bucket ragOf course, no one would intentionally wipe a hospital room surface with a towel carrying microbial contaminants. And most people would assume a towel soaking in disinfectant would be free from harmful bacteria. But according to a recent study published in the American Journal of Infection Control, 93 percent of laundered towels used for cleaning and 67 percent of towels soaked in disinfectant harbored viable bacteria. The study, Microbial contamination of hospital reusable cleaning towels, surveyed 10 major hospitals in Arizona and tested towels used for cleaning after laundering for the presence of viable bacteria. The researchers also sampled the buckets in which the towels were soaked in disinfectant.

Most hospitals use cotton towels soaked in disinfectant to clean patient rooms. The typical practice is to soak the towels in disinfectant, wring them out to wipe surfaces, and then wash them in-house or at a central laundering facility so they can be reused. Some hospitals in the study use microfiber cleaning towels, but those harbored significantly more bacteria than the cotton towels. Some of the bacteria found on the towels and disinfectant buckets are known to be involved in healthcare-associated infections (HAIs), including Klebsiella pneumonia, K oxytoca, and E coli.

While the study didn’t determine whether the presence of bacteria on the towels was due to insufficient laundering protocols or storage or handling of laundered towels, the researchers did note significant differences in the number and type of viable bacteria or microbial contaminants among the hospitals in the study. Further study is needed to analyze the reasons for those differences. Possibilities include variations in laundering and cleaning practices, towel materials, storage conditions, and methods of applying disinfectant.

 

 

PurThreadTM Technologies Inc. is dedicated to developing proprietary antimicrobial textile technology. Our patent-pending, integration technology and fiber formulations incorporate an EPA-registered antimicrobial additive into every fiber and yarn to protect the fabric from degradation. Learn more about our antimicrobial textile technology.

PurThread also makes a range of freshness products for other markets such as the military, emergency first responders and performance athletic wear in which our next-generation technology and fiber formulations expand the high performance options available to protect fabrics from odor, mold and mildew causing bacteria.

Our Store is Open for Business!

We’re very happy to announce that the PurThread Online Store is open for business, and our antimicrobial scrubs and lab coats are available for sale. You’ll also find our PurThread Sport golf shirt in the store. And, of course, this is just the beginning; we’re looking forward to adding more antimicrobial textile products as they become available.

We’ve been busily developing and testing our unique garments over the past few years, so we’re excited that we can now make them available for sale to individuals, as well as institutions. Our technology binds our proprietary active ingredient both in and on the fiber itself.  That process means that the antimicrobial agent’s effectiveness does not wash away over time. It also means that the resulting fabric has the same comfortable feel as similar untreated blended fabrics.

Starting today, you don’t have to take our word for it. We’re thrilled to be able to say “Head over to the PurThread Online Store and try one or more of our products for yourself.” Use coupon code PTB3938 and get free shipping on your first order. Happy shopping!

store-banner

 

PurThreadTM Technologies Inc. is dedicated to developing proprietary antimicrobial textile technology. Our patent-pending, integration technology and fiber formulations incorporate an EPA-registered antimicrobial additive into every fiber and yarn to protect the fabric from degradation. Learn more about our antimicrobial textile technology.

PurThread also makes a range of freshness products for other markets such as the military, emergency first responders and performance athletic wear in which our next-generation technology and fiber formulations expand the high performance options available to protect fabrics from odor, mold and mildew causing bacteria.